MUSCLE REGENERATION & REGENERATIVE MEDICINE

THREE-DIMENSIONAL CHROMATIN RE-ORGANIZATION DURING MUSCLE STEM CELL AGING

Benjamin A. Yang, Jacqueline A. Larouche, Kaitlyn M. Sabin, Paula M. Fraczek, Stephen C. J. Parker, Carlos A. Aguilar. Biorxiv (2022).

SPATIOTEMPORAL MAPPING OF IMMUNE AND STEM CELL DYSREGULATION AFTER VOLUMETRIC MUSCLE LOSS

Jacqueline A. Larouche, Emily C. Wallace, Bonnie D. Spence, Scott A. Johnson, Mangesh Kulkarni, Eric Buras, Bryan N. Brown, Stephen F. Badylak, Carlos A. Aguilar. Biorxiv (2022).

NEUTROPHIL AND NATURAL KILLER CELL IMBALANCES PREVENT MUSCLE STEM CELL MEDIATED REGENERATION FOLLOWING MURINE VOLUMETRIC MUSCLE LOSS

Jacqueline A. Larouche, Paula M. Fraczek, Sarah J. Kurpiers, Benjamin A. Yang, Carol Davis, Jesus A. Castor-Macias, Kaitlyn Sabin, Shannon Anderson, Julia Harrer, Matthew Hall, Susan V. Brooks, Young C. Jang, Nick Willett, Lonnie D. Shea, Carlos A. Aguilar. Proc. Nat'l. Acad. Sci. USA, 119 (15) e2111445119 (2022). Link to Data. Press

SESTRINS REGULATE MUSCLE STEM CELL METABOLIC HOMEOSTASIS

Benjamin A. Yang, Jesus Castor-Macias, Paula Fraczek, Ashley Cornett, Lemuel A. Brown, Myungjin Kim, Susan V. Brooks, Isabelle M.A. Lombaert, Jun Hee Lee, Carlos A. Aguilar. Stem Cell Reports, Vol. 16, Issue 9, 2078-2088 (2021). Link to Data.

MURINE MUSCLE STEM CELL RESPONSE TO PERTURBATIONS OF THE NEUROMUSCULAR JUNCTION ARE ATTENUATED WITH AGING

Jacqueline A. Larouche, Mahir Mohiuddin, Jeongmoon J Choi, Peter J Ulintz, Paula M Fraczek, Kaitlyn Sabin, Sethuramasundaram Pitchiaya, Sarah J Kurpiers, Jesus Castor-Macias, Wenxuan Liu, Robert Louis Hastings, Lemuel A Brown, James F Markworth, Kanishka De Silva, Benjamin D Levi, Sofia D Merajver, Gregorio Valdez, Joe V Chakkalakal, Young Jang, Susan Brooks, Carlos A Aguilar. eLife, Volume 10, e66749 (2021). Link to Data.

METABOLIPIDOMIC PROFILING REVEALS AN AGE- RELATED DEFICIENCY
OF SKELETAL MUSCLE PRO- RESOLVING MEDIATORS THAT CONTRIBUTES TO
MALADAPTIVE TISSUE REMODELING

James F. Markworth, Lemuel A. Brown, Eunice Lim, Jesus A. Castor-Macias, Jacqueline Larouche, Peter C. D. Macpherson, Carol Davis, Carlos A. Aguilar, Krishna Rao Maddipati, Susan V. Brooks. Aging Cell, Vol. 20, Issue 6, e13393 (2021).

ENGINEERED TOOLS TO STUDY INTERCELLULAR COMMUNICATION

Benjamin A. Yang, Trisha M. Westerhof, Kaitlyn Sabin, Sofia D. Merajver, Carlos A. Aguilar. Advanced Science, Vol. 8, Issue 3, 2002825 (2021).

REPROGRAMMING TO HELP THE OLD SEE LIKE THE YOUNG

Carlos A. Aguilar Science Translational Medicine Vol. 12, Issue 574, eabf7738 (2020).

RESOLVIN D1 SUPPORTS SKELETAL MYOFIBER REGENERATION VIA ACTIONS ON MYELOID AND MUSCLE STEM CELLS

CELLULAR SENOLYTICS

Carlos A. Aguilar. Science Translational Medicine 12 (550), eabd3075 (2020).

DISSECTING MURINE MUSCLE STEM CELL AGING THROUGH INTEGRATIVE GENOMIC ANALYSIS

Anna Shcherbina, Jacqueline Larouche, Benjamin A Yang, Lemuel A Brown, James F Markworth, Carolina Chung, Mehwish Khaliq, Kanishka de Silva, Jeongmoon J Choi, Mohammad F Sichani, Sriram Chandrasekaran, Young C Jang, Susan V Brooks, Carlos A. Aguilar. Cell Reports, Volume 32, Issue 4, 107964 (2020). Press Highlight. Link to Data

PRE-INNERVATED TISSUE ENGINEERED MUSCLE PROMOTES A PRO-REGENERATIVE MICROENVIRONMENT FOLLOWING VOLUMETRIC MUSCLE LOSS

Suradip Das, Kevin D. Browne, Franco A Laimo, Joseph C Maggiore, Halimulati Kaisaier, Carlos A. Aguilar, Zarina S Ali, Foteini Mourkioti, D. Kacy Cullen. Nature Communications Biology 3, 330 (2020).

RUNNING MAKES OLD STEM CELLS ACT YOUNG

Carlos A. Aguilar. Science Translational Medicine 12 (542), eabb7092 (2020).

REGENERATING MOTOR NEURONS PRIME MUSCLE STEM CELLS FOR MYOGENESIS BY ENHANCING PROTEIN SYNTHESIS AND MITOCHONDRIAL BIOENERGETICS

Jeongmoon J. Choi, Eun Jung Shin, Woojin M. Han, Shannon E. Anderson, Mahir Mohiuddin, Nan Hee Lee, Thu Tran, Shadi Nakhai, Hyeonsoo Jeong, Anna Shcherbina, Gunjae Jeong, Dong Gun Oh, Laura D. Weinstock, Sitara B. Sankar, Molly E. Ogle, Lida Katsimpardi, Tata Nageswara Rao, Levi Wood, Carlos A. Aguilar, Amy J. Wagers, Young C. Jang. Biorxiv, (2020).

HEMATOPOIETIC MALADAPTATION FACILITATES SEPTIC SCREENING

Carlos A. Aguilar. Science Translational Medicine 12 (534), eabb2768 (2020).

TRANSPLANTATION OF MUSCLE STEM CELL MITOCHONDRIA REJUVENATES THE BIOENERGETIC FUNCTION OF DYSTROPHIC MUSCLE

Mahir Mohiuddin, Jeongmoon J. Choi, Nan Hee Lee, Hyeonsoo Jeong, Shannon E. Anderson, Woojin M. Han, Berna Aliya, Tsvetomira Z. Peykova, Sumit Verma, Andrés J. García, Carlos A. Aguilar, Young C. Jang. Biorxiv, (2020).

TUNING MACROPHAGE PHENOTYPE TO MITIGATE SKELETAL MUSCLE FIBROSIS

David M. Stepien, Charles Hwang, Simone Marini, Chase A. Pagani, Michael Sorkin, Noelle D. Visser, Amanda K. Huber, Nicole J. Edwards, Shawn J. Loder, Kaetlin Vasquez, Carlos A. Aguilar, Ravi Kumar, Shamik Mascharak, Michael T. Longaker, Jun Li, Benjamin Levi. Journal of Immunology, 204 (8), 2203-2215 (2020).

NEW TECHNOLOGIES TO ENHANCE IN VIVO REPROGRAMMING FOR REGENERATIVE MEDICINE

Jacqueline Larouche, Carlos A Aguilar.

Trends in Biotechnology. 37:6, 604-617 (2019).

ROBUST INFLAMMATORY AND FIBROTIC SIGNALING FOLLOWING VOLUMETRIC MUSCLE LOSS: A BARRIER TO MUSCLE REGENERATION

Jacqueline Larouche, Sarah M. Greising, Benjamin T. Corona, Carlos A. Aguilar,. Cell Death Disease, 9: 409 (2018).

MULTISCALE ANALYSIS OF A REGENERATIVE THERAPY FOR TREATMENT OF VOLUMETRIC MUSCLE LOSS INJURY

Carlos A. Aguilar, Sarah M. Greising, Alain Watts, Stephen M. Goldman, Chelsea Peragallo, Christina Zook, Jacqueline Larouche, Benjamin T. Corona. Cell Death Discovery, 4: 33 (2018). Link to data (This paper was listed as best of 2018 and 2019 by the journal).

UNWAVERING PATHOBIOLOGY OF VOLUMETRIC MUSCLE LOSS INJURY

Sarah M. Greising, Jessica C. Rivera, Stephen M. Goldman, Alain Watts, Carlos A. Aguilar, Benjamin T. Corona. Scientific Reports. 7: 13179 (2017). Link to data

RNA TRANSCRIPT EXPRESSION OF IGF-1:PI3K PATHWAY COMPONENTS IN REGENERATING SKELETAL MUSCLE IS SENSITIVE TO INITIAL INJURY INTENSITY

Ronald W. Matheny Jr., Christopher T. Carrigan, Mary N. Abdalla, Alyssa V. Geddis, Luis A. Leandry, Carlos A. Aguilar, Stuart S. Hobbs, Maria L. Urso. Growth Hormone & IGF Research, Vol. 32, Pages 14-21 (2017).

TRANSCRIPTIONAL AND CHROMATIN DYNAMICS OF MUSCLE REGENERATION AFTER SEVERE TRAUMA

Carlos A. Aguilar, Ramona Pop, Anna Shcherbina, Alain Watts, Ronald W. Matheny Jr., Davide Cacchiarelli,Woojin M. Han, Eunjung Shin, Shadi A. Nakhai, Young C. Jang, Christopher T. Carrigan, Casey A. Gifford, Melissa A. Kottke, Marcella Cesana, Maria L. Urso, Alexander Meissner. Stem Cell Reports, Volume 7, Issue 5, Pages 983–997 (2016). Link to Data. F1000 Recommendation.

IN VIVO MONITORING OF TRANSCRIPTIONAL DYNAMICS AFTER LOWER-LIMB MUSCLE INJURY ENABLES QUANTITATIVE CLASSIFICATION OF HEALING

Carlos A. Aguilar, Anna Shcherbina, Darrell O. Ricke, Ramona Pop, Christopher T. Carrigan, Casey A. Gifford, Maria L. Urso, Melissa A. Kottke, Alexander Meissner. Scientific Reports. 5:13885 (2015). Link to Data

BIO & NANOMATERIALS

PRE-INNERVATED TISSUE ENGINEERED MUSCLE PROMOTES A PRO-REGENERATIVE MICROENVIRONMENT FOLLOWING VOLUMETRIC MUSCLE LOSS

Suradip Das, Kevin D. Browne, Franco A Laimo, Joseph C Maggiore, Halimulati Kaisaier, Carlos A. Aguilar, Zarina S Ali, Foteini Mourkioti, D. Kacy Cullen. Nature Communications Biology 3, 330 (2020).

NEW TECHNOLOGIES TO ENHANCE IN VIVO REPROGRAMMING FOR REGENERATIVE MEDICINE

Jacqueline Larouche, Carlos A Aguilar.

Trends in Biotechnology. 37:6, 604-617 (2019).

UNWAVERING PATHOBIOLOGY OF VOLUMETRIC MUSCLE LOSS INJURY

Sarah M. Greising, Jessica C. Rivera, Stephen M. Goldman, Alain Watts, Carlos A. Aguilar, Benjamin T. Corona. Scientific Reports. 7: 13179 (2017). Link to data

PROBING ELECTRONIC PROPERTIES OF MOLECULAR ENGINEERED ZINC OXIDE NANOWIRES WITH PHOTOELECTRON SPECTROSCOPY

Carlos A. Aguilar, Richard Haight, Anastassios Mavrokefalos, Brian A. Korgel, Shaochen Chen. ACS Nano, Volume 3, Issue 10, Pages 3057-3062 (2009).

DIRECT MICRO-PATTERNING OF BIODEGRADABLE POLYMERS USING ULTRAVIOLET AND FEMTOSECOND LASERS

Carlos A. Aguilar, Yi Lu, Samuel Mao, Shaochen Chen. Biomaterials, Volume 26, Issue 36, Pages 7642–7649 (2005).

MICRO/NANOFLUIDIC DEVICES

DIRECT ANALYSIS OF GENE SYNTHESIS REACTIONS USING SOLID-STATE NANOPORES

Spencer Carson, Scott T. Wick, Peter A. Carr, Meni Wanunu, Carlos A. Aguilar. ACS Nano, Volume 9, Issue 12, Pages 12417–12424 (2015).

MICRO- AND NANOSCALE DEVICES FOR THE INVESTIGATION OF EPIGENETICS AND CHROMATIN DYNAMICS

Carlos A. Aguilar, Harold G. Craighead. Nature Nanotechnology, Volume 8, Pages 709-718 (2013).

INTEGRATION OF SOLID-STATE NANOPORES IN MICROFLUIDIC NETWORKS VIA TRANSFER PRINTING OF SUSPENDED MEMBRANES

Tarun Jain, Ricardo Jose S. Guerrero, Carlos A. Aguilar, Rohit Karnik. Analytical Chemistry, Volume 85, Pages 3871−3878 (2013).

ENHANCED DISCRIMINATION OF DNA MOLECULES IN NANOFLUIDIC CHANNELS THROUGH MULTIPLE MEASUREMENTS

Yi-Heng Sen, Tarun Jain, Carlos A. Aguilar, Rohit Karnik. Lab on a Chip, Volume 12, Pages 1094–1101 (2012).